Motif ID: NFY{A,B,C}.p2

Z-value: 5.225


Transcription factors associated with NFY{A,B,C}.p2:

Gene SymbolEntrez IDGene Name
NFYA 4800 nuclear transcription factor Y, alpha
NFYB 4801 nuclear transcription factor Y, beta
NFYC 4802 nuclear transcription factor Y, gamma

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NFYCchr1_+_411574280.721.2e-36Click!
NFYAchr6_+_41040713-0.321.2e-06Click!
NFYBchr12_-_1045318750.152.8e-02Click!


Activity profile for motif NFY{A,B,C}.p2.

activity profile for motif NFY{A,B,C}.p2


Sorted Z-values histogram for motif NFY{A,B,C}.p2

Sorted Z-values for motif NFY{A,B,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFY{A,B,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_91926109 194.367 NM_001827
 CKS2
CDC28 protein kinase regulatory subunit 2
chr14_+_54863672 159.261 NM_001130851
NM_005192
 CDKN3

cyclin-dependent kinase inhibitor 3

chr1_-_197115566 143.977 NM_001206846
NM_018136
 ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

chr17_-_38574042 142.957 NM_001067
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr4_-_174255454 139.247 NM_001130688
NM_002129
 HMGB2

high mobility group box 2

chr2_+_10262853 129.632 NM_001034
 RRM2
ribonucleotide reductase M2
chr1_-_153643456 127.508 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_153643433 116.836 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_153643417 115.330 ILF2
interleukin enhancer binding factor 2, 45kDa
chr5_+_68462948 113.383 CCNB1
cyclin B1
chr1_-_153643428 111.296 ILF2
interleukin enhancer binding factor 2, 45kDa
chr2_+_10262694 111.171 NM_001165931
 RRM2
ribonucleotide reductase M2
chr19_-_55919324 109.834 NM_014501
 UBE2S
ubiquitin-conjugating enzyme E2S
chr20_+_47662782 108.484 NM_001316
 CSE1L
CSE1 chromosome segregation 1-like (yeast)
chr5_+_177631496 106.039 NM_004499
NM_031266
 HNRNPAB

heterogeneous nuclear ribonucleoprotein A/B

chr5_+_68462985 105.158 CCNB1
cyclin B1
chr14_+_58711599 104.525 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr2_-_61765394 103.742 NM_003400
 XPO1
exportin 1 (CRM1 homolog, yeast)
chr1_+_154947166 103.633 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr5_+_177631533 102.484 HNRNPAB
heterogeneous nuclear ribonucleoprotein A/B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 175 entries
enrichment   p-value GO term description
10.57 1.29e-03 GO:0000085 G2 phase of mitotic cell cycle
10.57 1.29e-03 GO:0051319 G2 phase
10.07 1.38e-02 GO:0002566 somatic diversification of immune receptors via somatic mutation
10.07 1.38e-02 GO:0016446 somatic hypermutation of immunoglobulin genes
7.55 6.18e-08 GO:0006695 cholesterol biosynthetic process
7.16 1.13e-08 GO:0016126 sterol biosynthetic process
5.93 1.78e-03 GO:0006271 DNA strand elongation involved in DNA replication
5.54 4.02e-03 GO:0022616 DNA strand elongation
5.49 2.01e-05 GO:0000819 sister chromatid segregation
5.44 4.28e-02 GO:0002200 somatic diversification of immune receptors
5.16 4.31e-04 GO:0000070 mitotic sister chromatid segregation
5.04 1.18e-02 GO:0051297 centrosome organization
5.04 3.20e-02 GO:0071174 mitotic cell cycle spindle checkpoint
4.99 9.68e-13 GO:0065004 protein-DNA complex assembly
4.93 1.18e-04 GO:0007051 spindle organization
4.86 9.70e-13 GO:0071824 protein-DNA complex subunit organization
4.76 1.25e-09 GO:0006334 nucleosome assembly
4.73 2.34e-08 GO:0000236 mitotic prometaphase
4.67 8.73e-10 GO:0031497 chromatin assembly
4.52 2.14e-12 GO:0006323 DNA packaging

Gene overrepresentation in compartment category:

Showing 1 to 20 of 72 entries
enrichment   p-value GO term description
9.44 2.54e-02 GO:0042555 MCM complex
8.24 1.22e-02 GO:0000780 condensed nuclear chromosome, centromeric region
6.71 3.67e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
4.78 2.13e-06 GO:0000786 nucleosome
4.29 2.14e-08 GO:0032993 protein-DNA complex
4.12 7.57e-04 GO:0000794 condensed nuclear chromosome
3.99 5.74e-05 GO:0000777 condensed chromosome kinetochore
3.95 3.42e-06 GO:0000776 kinetochore
3.92 3.60e-05 GO:0000779 condensed chromosome, centromeric region
3.84 1.98e-03 GO:0030496 midbody
3.80 1.45e-09 GO:0000793 condensed chromosome
3.66 1.88e-03 GO:0000922 spindle pole
3.55 1.34e-10 GO:0005819 spindle
3.51 6.10e-08 GO:0000775 chromosome, centromeric region
3.47 2.00e-09 GO:0044454 nuclear chromosome part
3.20 2.42e-26 GO:0005694 chromosome
3.17 3.90e-21 GO:0044427 chromosomal part
3.17 2.35e-09 GO:0000228 nuclear chromosome
3.15 2.95e-10 GO:0000785 chromatin
3.06 7.38e-03 GO:0042470 melanosome

Gene overrepresentation in function category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
4.24 3.11e-04 GO:0003697 single-stranded DNA binding
4.15 2.32e-02 GO:0003678 DNA helicase activity
3.86 4.81e-02 GO:0042826 histone deacetylase binding
3.36 2.93e-02 GO:0008094 DNA-dependent ATPase activity
2.83 1.77e-03 GO:0016853 isomerase activity
2.69 4.63e-03 GO:0003690 double-stranded DNA binding
2.53 8.69e-04 GO:0043566 structure-specific DNA binding
2.44 2.85e-03 GO:0003682 chromatin binding
1.92 1.03e-07 GO:0003723 RNA binding
1.89 3.02e-02 GO:0016887 ATPase activity
1.77 1.24e-04 GO:0019899 enzyme binding
1.67 1.26e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.66 2.00e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.65 3.14e-03 GO:0016462 pyrophosphatase activity
1.65 4.83e-03 GO:0017111 nucleoside-triphosphatase activity
1.45 8.02e-34 GO:0005515 protein binding
1.45 1.82e-03 GO:0030554 adenyl nucleotide binding
1.45 2.46e-03 GO:0005524 ATP binding
1.44 3.45e-03 GO:0032559 adenyl ribonucleotide binding
1.41 8.75e-05 GO:0000166 nucleotide binding